Haematology summray 11

Chapter 11 in Haematology (Haematological malignancy:aetiology and genetics) summary

 

-The haemopoietic malignancies are clonal diseases that derive from a single cell in the marrow or peripheral lymphoid tissue which has undergone genetic alteration.

-They represent approximately 7% of all mlignant disease.

-inherited and envirmental factor both predispose to tumour development but the relative contribution of these is usually unclear.

-infections (viral and bacterial),drugs, radiation and chemicals can all inrease the risk of developing a haemopoietic malignancy.

-Haematological malignancies occur because of genetic alteration that lead to increased activation oncogenes or decreased activity of tumour suppressor genes.

-These genetic alterations may occur through avarity of mechanisms such as point mutation, chromosomal, traslocation, or gene deletion .

-Important investigation include study of the chromosomes (karyotype analysis),FISH,PCR, microtarry analysis,flow cytometry and immunohistochmeistry.

-These investigations guide the diagnosis treatment and moitoring for residual disease of individual cases.

 

From book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION