Haematology summray 3

Chapter 3 in hematology ( Hypochromic anemia) summary

-          -Iron is present in the body in haemoglobin,myoglobin, haemosiderin and ferritin , and in iron-containing enzymes, transferrin is the main transport protien in blood and hepcidin the main regular of iron absorption and iron relese from macrophages.

- Iron Metabolism is regulated according to iron status by intracellular iron regulatory protiens and by control of hepcidin synthesis.

-Iron Deficiency is the most common cause of anaemia throughout the world. The surm ferritin, serum iron and saturation of the iron binding capacity are reduced.

-In western countries, it is usually caused by haemorrhage from the gastrointestinal or the female genital tract.dietary in take is important particulary i underdeveloped countries.

-The red cells are hypochromic and microcytic. It is treated by oral or parenteral iron and by treating, as far as possible, the underlying cause.

-Other ferquent causes of a hypochromic, microcytic anaemia are the anaemia of chronic disorders, which occures in patients with chronic inflammatory or malignant diseases, and alph or beta thalassaemia.less frequent causes include sideroblastic anemia (some cases) and lead poisoning.

-Sideroblastic anaemia are chracterised by frequent ring siderobalsts in the marrow.

The most frequent is sub-type of myelodyplasia .

 

From book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION