Heamatology summary 12

Chapter 12 in Haematology (Haematoloical malignancy: managment) summary

-Progress in the treatment of haemopoietic malignancies has been the result of improvemnets in both supportive therapy and speicific tumour treatments.

-Supportive treatments often include: insertion of a central nevous catheter;

Appropriate use of red cell and platelet transfusions;

Early administration of drugs to traet infection;Otimiziation of the blood coagulation system Drugs to reduce side effects such as nausea or pain;Psychological support.

-Gram-positive skin organisms such as staphyloccus are common infections and often colonize central venous catheters.

-Gram-Negative bacteria are usually derived from the gut and and can cause severe septicemia.

-The use of air filters,handwashing and antibiotics can reduce infection rates .

-Neutropenic patients who developa fever should be treated urgently with broad-spectrum antibiotics.

-Herpes viruses are a common cause of infection in patients who are significantly immunosuppressed.

-Fungal infections are a major clinical problem for patients undergoing chemotherapy.antifungal drugs may be used for either prevention or treatment of disease.

-A wide range of drugs is now available for the treatment  of haemopoietic malignancy:

Alkylating agents,antimetabolites,anthracyclines,folate antagonists,signal transduction inhibitors,steroids,monoclonal antibodies;immune modulators,proteasome inhibitors and inhibitors of mitosis.

From book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION